PUBLICATIONS

Recent featured publications:

Lei, Y., Liang, X., Sun, Y., Yao, T., Gong, H., Chen, Z., Gao, Y., Wang, H., Wang, R., Huang, Y., Yang, T., Yu, M., Liu, L., Yi, C., Wu, Q.F., Kong, X., Xu, X., Liu, S.*, Zhang, Z.*, Liu, T.* (2024) Region-specific transcriptomic responses to obesity and diabetes in macaque hypothalamus. Cell Metab. 36(2):438-453.e6.

Li, H., J, T., An, S., Xu, M., Guo, L., Ren, B., Shi, X., Wang, X., Yan, J., Yuan, J., Xu, X., Wu, Q.F., Luo, Q., Gong, H., Bian, W.*, Li, A.*, Yu, X.* (2024) Single-neuron projectomes of mouse paraventricular hypothalamic nucleus oxytocin neurons reveal mutually exclusive projection patterns. Neuron. S0896-6273(23)01010-3.

Sun, X., Chen, Z., Guo, X., Wang, J., Ge, M., Wong, S.Z.H., Wang, T., Li, S., Yao, M., Johnston, L.A., Wu, Q.F.* (2023) Stem cell competition driven by Axin2-p53 axis controls brain size during murine development. Dev Cell. 58(9):744-759.e11.

Zhuang, Y., Li, Z., Xiong, S., Sun, C., Li, B., Wu, S., Li, J., Shi, X., Yang, L., Chen, Y., Bao, Z., Li, X., Sun, C., Chen, Y., Deng, H., Li, T., Wu, Q.F., Qi, L., Huang, Y., Yang, X.*, Lin, Y.* (2023) Circadian clocks are modulated by compartmentalized oscillating translation. Cell. 186(15):3245-3260.e23.

Shi, X., Zhuang, Y., Chen, Z., Xu, M., Kuang, J., Sun, X.L., Gao, L, Kuang, X., Zhang, H., Li, W., Wong, S.Z.H., Liu, C., Liu, L., Jiang, D., Pei, D., Lin, Y.*, Wu, Q.F.* (2022) Hierarchical deployment of Tbx3 dictates the identity of hypothalamic KNDy neurons to control puberty onset. Sci Adv. 8, eabq2987. DOI: 10.1126/sciadv.abq2987

Ge, M., Sheikhshahrokh, A., Shi, X., Zhang, Y.H., Xu, Z., Wu, Q.F.* (2022) A Spacetime Odyssey of Neural Progenitors to Generate Neuronal Diversity. Neurosci. Bull. 39, 645-658.

DOI: 10.1007/s12264-022-00956-0

Chen, A., Liao, S., Cheng, M., Ma, K., Wu, L., Lai, Y., Qiu, X., Yang, J., Xu, J., Hao, S., Wang, X., Lu, H., Chen, X., Liu, X., Huang, X., Li, Z., Hong, Y., Jiang, Y., Peng, J., Liu, S., Shen, M., Liu, C., Li, Q., Yuan, Y., Wei X., Zheng, H., Feng, W., Wang Z., Liu, Y., Wang, Z., Yang, Y., Xiang, H., Han, L., Qin, B., Guo, P., Lai, G., Muñoz-Cánoves, P., Maxwell, P.H., Thiery, J.P., Wu, Q.F., Zhao, F., Chen, B., Li, M., Dai, X., Wang, S., Kuang, H., Hui, J., Wang, L., Fei, J.F., Wang, O., Wei, X., Lu, H., Wang, B., Liu, S., Gu, Y., Ni, M., Zhang, W., Mu, F., Yin, Y., Yang, H., Lisby, M., Cornall, R.J., Mulder, J., Uhlén, M., Esteban, M.A.*, Li, Y.*, Liu, L.*, Xu, X.*, Wang, J.* (2022) Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays. Cell. 185, 1777-1792.

Zhao, Z., Zhang, D., Yang, F., Xu, M., Zhao, S., Pan, T., Liu, C., Liu, Y., Wu, Q.F., Tu, Q., Zhou, P., Li, R., Kang, J., Zhu, L., Gao, F., Wang, Y.*, Xu Z.* (2022) Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing. Cell Res. 32, 425-436.

Yan, Y., Tian, M., Li, M., Zhou, G., Chen, Q., Xu, M., Hu, Y., Luo, W., Guo, X., Zhang, Cheng., Xie, H., Wu, Q.F., Xiong, W.*, Liu, S.*, Guan, J.* (2022) ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder. Neuron. 110, 1156-1172.

Chen, Z., Li, S., Xu, M., Liu, C., Ye, H., Wang, B., Wu, Q.F.* (2022) Single-cell Transcriptomic Profiling of the Hypothalamic Median Eminence during Aging. J Genet Genomics. 49, 523-536. doi: 10.1016/j.jgg.2022.01.001.

Wang, A., Wang, J., Tian, K., Huo, D., Ye, H., Li, S., Zhao, C., Zhang, B., Zheng, Y., Xu, L., Hua, X., Wang, K., Wu, Q.F., Wu, X., Zeng, T., Liu, Y., Zhou, Y.* (2021) An epigenetic circuit controls neurogenic programs during neocortex development. Development. 148 (22): dev199772.

Zhang, Y., Xu, M., Shi, X., Sun, X.L., Mu, W., Wu, H., Wang, J., Li, S., Su, P., Gong, L., He, M., Yao, M., Wu, Q.F.* (2021) Cascade diversification directs generation of neuronal diversity in the hypothalamus. Cell Stem Cell. 28, 1483-1499.

Mu, W., Li, S., Xu, J., Guo, X., Wu, H., Chen, Z., Qiao, L., Helfer, G., Lu, F., Liu, C., Wu, Q.F.* (2021) Hypothalamic Rax+ tanycytes contribute to tissue repair and tumorigenesis upon oncogene activation in mice. Nat Commun. 12, 2288.

Wang J., Li T., Wang J., Xu Z., Meng W., Wu, Q.F.* (2020) Talpid3-Mediated Centrosome Integrity Restrains Neural Progenitor Delamination to Sustain Neurogenesis by Stabilizing Adherens Junctions. Cell Rep. 33, 108495.

Berg, D.A., Su, Y., Jimenez-Cyrus, D., Patel, A., Huang, N., Morizet, D., Lee, S., Shah, R., Rojas Ringeling F., Jain, R., Epstein, J.A., Wu, Q.F., Canzar, S., Ming, G.L., Song, H., and Bond, A.M. (2019) A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis. Cell. 18, 654-668.

Tang, C., Wang, M., Wang, P., Wang, L., Wu, Q., and Guo, W. (2019). Neural Stem Cells Behave as a Functional Niche for the Maturation of Newborn Neurons through the Secretion of PTN. Neuron. 101, 32-44.

Wong, S.Z.H., Scott, E.P., Mu, W., Guo, X., Borgenheimer, E., Freeman, M., Ming, G.L., Wu, Q.F.*, Song, H., and Nakagawa, Y. (2018). In vivo clonal analysis reveals spatiotemporal regulation of thalamic nucleogenesis. PLoS Biol. 16, e2005211.

All publications:

Han, L., Liu, Z., Jing, Z., Liu, Y., Chang, H., Lei, J., Peng, Y., Wang, K., Xu, Y., Liu, W., Wu, Z., Li, Q., Shi, X., Zheng, M., Wang, H., Deng, J., Zhong, Y., Pan, H., Lin, J., Zhang, R., Chen, Y., Wu, J., Xu, M., Ren, B., Cheng, M., Yu, Q., Song, X., Wei, Y., Zhang, S., Dou, Y., Zhao, Y., Han, L., Zhu, Q., Xu, Y., Wang, S., Chen, H., Wang, D., Bai, Y., Liang,Y., Liu, Y., Chen, M., Xie, C., Bo, B., Li, M., Zhang, X., Ting, W., Chen, Z., Fang, J., Li, S., Jiang, Y., Tan, X., Zou, G., Xie, Y., Li, H., Tao, Q., Li, Y., Liu, J., Liu, Y., Hao, M., Wang, J., Wen, H., Liu, J., Yan, Y., Zhang, H., Sheng,Y., Han, M., Yu, S., Liao, X., Jiang, X., Wang, G., Liu, H., Wang, C., Feng, N., Liu, X., Ma, K., Xu, J., Han, T., Cao, H., Zheng, H., Chen, Y., Lu, H., Yu, Z., Zhang, J., Wang, B., Wang, Z., Xie, Q., Pan, S., Liu, C., Xu, C., Cui, L., Li, Y., Liu, S., Liao, S., Chen, A., Wu, Q.F., Wang, J., Liu, Z., Sun, Y., Mulder, J., Yang, H., Wang, Y.*, Li, C.*, Yao, J.*, Xu, X.*, Liu, L.*, Shen, Z.*, Wei, W.*, Sun, Y.* (2023) Spatially resolved molecular and cellular atlas of the mouse brain. bioRxiv. https://www.biorxiv.org/content/10.1101/2023.12.03.569501v1

Miao, Y., Fan, K., Peng, X., Li, S., Chen, J., Bai, R., Wei, Y., Deng, Y., Zhao, C.*, Wu, Q.F.*, Ge, M*., Gong, J.*, Wu, D.* (2023) Postoperative hypothalamic-pituitary dysfunction and long-term hormone replacement in patients with childhood-onset craniopharyngioma. Front Endocrinol.14:1241145.

Yao, Y., Chen, Z., Wu, Q.F., Lu, Y.*, Zhou X.*, Zhu, X.* (2023) Single-cell RNA sequencing of retina revealed novel transcriptional landscape in high myopia and underlying cell-type-specific mechanisms. MedComm. 4(5):e372.

Zhu, X., Meng, J., Han, C.,Wu, Q.F., Du, Y., Qi, J., Wei, L., Li, H., He, W., Zhang, K., Lu, Y.* (2023) CCL2-mediated inflammatory pathogenesis underlies high myopia-related anxiety. Cell Discov. 9(1):94. doi: 10.1038/s41421-023-00588-2.

Yao, Y., Wei, L., Chen, Z., Li, H., Qi, J., Wu, Q.F., Zhou, X., Lu, Y., Zhu, X.* (2023) Single-cell RNA sequencing: Inhibited Notch2 signalling underlying the increased lens fibre cells differentiation in high myopia. Cell Prolif. 56(8):e13412.

Ge, M., Sheikhshahrokh, A., Shi, X., Zhang, Y.H., Xu, Z., Wu, Q.F.* (2022) A Spacetime Odyssey of Neural Progenitors to Generate Neuronal Diversity. Neurosci. Bull. 39, 645-658.

DOI: 10.1007/s12264-022-00956-0

Hong, H., Zhao, Z., Huang, X., Guo, C., Zhao, H., Wang, G., Zhang, Y.P., Zhao, J.P., Shi, J., Wu, Q.F., Jiang, Y.H., Wang, Y., Li, L.M., Du, Z., Zhang, Y.Q.*, Xiong, Y.* (2022) Comparative proteome and cis-regulatory element analysis reveals specific molecular pathways conserved in dog and human brains. Mol Cell Proteomics. 21, 100261

Wu, H.*, Fu, R., Zhang, Y.H., Liu, Z., Chen, Z., Xu, J., Tian, Y.*, Jin, W.*, Wong, S.Z.H.*, Wu, Q.F. (2022) Single-cell RNA sequencing unravels upregulation of immune cell crosstalk in relapsed pediatric ependymoma. Front Immunol. 13, 903246.

Yun. H., Dumbell, R., Hanna, K., Bowen, J., Mclean, S.L., Kantamneni, S., Pors, K., Wu, Q.F., Helfer, G.* (2022) The chemerin-CMKLR1 axis is functionally important for central regulation of energy homeostasis. Front Physiol. 13, 897105.

Wu, H., Fu, R., Zhang, Y.H., Liu, Z., Chen, Z., Xu, J., Tian, Y., Jin, W., Wong, S.Z.H., Wu Q.F. (2022) Single-cell RNA Sequencing of Pediatric Ependymoma Unravels Subclonal Heterogeneity Associated with Patient Survival. bioRxiv. https://www.biorxiv.org/content/10.1101/2022.02.26.48 2082v1.

Wen, Q., Weng, H., Liu, T., Yu, L., Zhao, T., Qin, J., Li, S., Wu, Q.F., Tissir, F., Qu, Y., Zhou, L.* (2022) Inactivating Celsr2 promotes motor axon fasciculation and regeneration in mouse and human. Brain. 145(2): 670–683.

Zhu, X., Du, Y., Li, D., Xu, J., Wu, Q.F., He, W., Zhang, K., Zhu, J., Guo, L., Qi, M., Liu, A., Qi, J., Wang, G., Meng, J., Yang, Z., Zhang, K., Lu, Y. (2021) Aberrant TGF-β1 signaling activation by MAF underlies pathological lens growth in high myopia. Nat Commun. 12, 2102.

Chang, Y., Jiang, Y., Li, C., Wang, Q., Zhang, F., Qin, C.F., Wu, Q.F., Li, J., Xu, Z. (2021) Different Gene Networks are Disturbed by Zika Virus Infection in a Mouse Microcephaly Model. Genom. Proteom. Bioinform. 18, 737-748.

Zhang, Y., Xu, M., Li, S., Wu, H., Shi, X., Guo, X., Mu, W., Gong, L., Yao, M., He, M., Wu, Q.F.*(2020) Cascade Diversification Directs the Generation of Neuronal Diversity in Hypothalamus. bioRxiv. 125054.

Xu, M., Wang, J., Guo, X., Li, T., Kuang, X., Wu, Q.F.* (2018) Illumination of neural development by in vivo clonal analysis. Cell Regen. 12, 33-39.

Helfer, G., and Wu, Q.F.* (2018). Chemerin: a multifaceted adipokine involved in metabolic disorders. J Endocrinol. 238, R79-R94.

Wei, D., Gao, N., Li, L., Zhu, J.X., Diao, L., Huang, J., Han, Q.J., Wang, S., Xue, H., Wang, Q., Wu, Q.F., Zhang, X., and Bao, L. (2017). alpha-Tubulin acetylation restricts axon overbranching by dampening microtubule plus-end dynamics in neurons. Cereb Cortex. 28, 3332-3346.

Yoon, K.J., Song, G., Qian, X., Pan, J., Xu, D., Rho, H.S., Kim, N.S., Habela, C., Zheng, L., Jacob, F., Zhang, F., Lee, E.M., Huang, W.K., Ringeling, F.R., Vissers, C., Li, C., Yuan, L., Kang, K., Kim, S., Yeo, J., Cheng, Y., Liu, S., Wen, Z., Qin, C.F., Wu, Q., Christian, K.M., Tang, H., Jin, P., Xu, Z., Qian, J., Zhu, H., Song, H., and Ming, G.L. (2017). Zika-virus-encoded NS2A disrupts mammalian cortical neurogenesis by degrading adherens junction proteins. Cell Stem Cell. 21, 349-358.

Oh, Y., Zhang, F., Wang, Y., Lee, E.M., Choi, I.Y., Lim, H., Mirakhori, F., Li, R., Huang, L., Xu, T., Wu, H., Li, C., Qin, C.F., Wen, Z., Wu, Q.F., Tang, H., Xu, Z., Jin, P., Song, H., Ming, G.L., Lee, G. (2017). Zika virus directly infects peripheral neurons and induces cell death. Nat Neurosci. 20, 1209-1212.

Yang, L., Dong, F., Yang, Q., Yang, P.F., Wu, R., Wu, Q.F., Wu, D., Li, C.L., Zhong, Y.Q., Lu, Y.J., Cheng X, Xu FQ, Chen L, Bao L, Zhang X. (2017). FGF13 selectively regulates heat nociception by interacting with Nav1.7. Neuron. 93, 806-821.

Liu, H., Wu, Q.F., Li, J.Y., Liu, X.J., Li, K.C., Zhong, Y.Q., Wu, D., Wang, Q., Lu, Y.J., Bao, L., Zhang X. (2015). Fibroblast growth factor 7 is a nociceptive modulator secreted via large dense-core vesicles. J Mol Cell Biol. 7, 466-475.

Zhang, X., Bao, L., Yang, L., Wu, Q., and Li, S. (2012). Roles of intracellular fibroblast growth factors in neural development and functions. Sci China Life Sci. 55, 1038-1044.

Wu, Q.F., Yang, L., Li, S., Wang, Q., Yuan, X.B., Gao, X., Bao, L., and Zhang, X. (2012). Fibroblast growth factor 13 is a microtubule-stabilizing protein regulating neuronal polarization and migration. Cell. 149, 1549-1564.

Liu, X.J., Zhang, F.X., Liu, H., Li, K.C., Lu, Y.J., Wu, Q.F., Li, J.Y., Wang, B., Wang, Q., Lin, L.B., Zhong, Y.Q., Xiao, H.S., Bao, L., and Zhang, X. (2012). Activin C expressed in nociceptive afferent neurons is required for suppressing inflammatory pain. Brain. 135, 391-403.